Saturday, January 20, 2007

First case of sleeping sickness reported in India

Medindia.com: The first case of human trypanosomiasis has now been discovered in India. Sleeping sickness or Human trypanosomiasis is endemic in Africa and in South America, where it is called Chagas disease.

A farmer in India, from the village of Shivani (district of Chandrapur) 140 km from Nagpur in the central State of Maharashtra, has recently been identified as the first confirmed case of human trypanosomiasis recorded in this country.

Human trypanosomiasis in Africa is caused by Trypanosoma brucei gambiense and Chagas disease in South America is induced by T.cruzi. In other regions of the world such as India, only animals were up to now known to be infected by certain trypanosomes, which are not pathogenic for humans.

In December 2004, a researcher form the IRD centre in Montpellier, a specialist in the African form of human trypanosomiasis (sleeping sickness), undertook the identification of the pathogenic agent, at the request of the Indian authorities and mandated by the WHO in collaboration with local medical services (1). Morphological examination of parasites contained in the patient’s blood revealed the presence of many trypanosomes belonging to the species T. evansi, which usually infects animals, particularly cattle.

The patient, who had been suffering for several months from recurring bouts of fever, had very high blood parasite count, equal or greater than 106 parasites/ml of blood. Parasitological, serological and molecular analyses confirmed this result. It is the world’s first formally identified case of human trypanosomiasis caused by T. evansi.

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